School of Medicine - Basic Medical SciencePathology II

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40年誌写真-2

Our main research projects are the investigation of molecular mechanism of invasion and metastasis of both lung cancer and bone/soft tissue sarcomas and the cytogenetic approach to tumors with FISH. We have also been doing research on several neoplastic and non-neoplastic diseases, including tissue engineering of auricular cartilage with tissue mesenchymal stem cells, steroid induced osteonecrosis and with doctoral and post-doctoral fellows from some clinical departments. We hope to integrate classic morphological pathology with novel molecular pathology by means of sophisticated experimental technologies, utilizing not only surgical materials but also cultured cells and experimental animal models with gene-modification.

Contact Information

TEL: 076-286-2211 +81-76-286-2211 / FAX: 076-286-2484 +81-76-286-2484 / Email: z-ueda@kanazawa-med.ac.jp

Faculty

Professor and Chair

  • UEDA Yoshimichi 上田教授

Associate Professor

  • SATO Katsuaki

Assistant Professor

  • SHIMAZAKI Miyako

Technical Assistant

  • TANIGUCHI Ayaka

Secretary

  • IKEBAYASI Mizue

Research Achievements

Research Activities

  • Yasuo Sakai, Lihua Tang, Yoshimichi Ueda and Shogo Katsuda: Effects of oral administration of tripeptides derived from type I collagen (collagen tripeptide) on atherosclerosis development in hypercholesterolemic rabbits.
    J Biosci Bioengineer (JBIOSC) 119: 558-63, 2015
  • Ichiseki T, Kanefuji A, Ueda Y, Nakagawa S, Mikami T, Fukui K, Matsumoto T:
    Osteonecrosis development in a novel rat model characterized by a single application of oxidative stress. Arthritis Rheum 63: 2138-41,2011.
  • Yuichiro Machida, Yoshimichi Ueda, Miyako Shimasaki, Katsuaki Sato, Motoyasu Sagawa, Shogo Katsuda and Tsutomu Sakuma: Relationship of aquaporin 1, 3 and 5 expression in lung cancer cells to cellular differentiation, invasive growth and metastasis potential. Hum Pathol 42: 669-78, 2011.
  • Yoshimitsu Kanazawa, Yoshimichi Ueda, Miyako Shimasaki, Shogo Katsuda, Norio Yamamoto, Katsuro Tomita, Hiroyuki Tsuchiya: Down Regulation of Plakoglobin in Soft Tissue Sarcoma Is Associated with a Higher Risk of Pulmonary Metastasis. Anticancer Res 28:655-64, 2008.
  • Katsuaki Sato, Yoshimichi Ueda, Junichi Sugaya, Mamoru Ozaki, Masanori Hisaoka, Shogo Katsuda: Extrauterine endometrial stromal sarcoma with JAZF1/JJAZ1 fusion confirmed by RT-PCR and interphase FISH presenting as an inguinal tumor. Virchows Archives 450:349-53, 2007.

External Research Funding

  • Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan, 2014-6, to Yochimichi Ueda, entitled “Involvement of membrane sphingolipid in the invasion and metastasis of pulmonary adenocarcinoma”.
  • Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan, 2011-3, to Yochimichi Ueda, entitled “Identification of aquaporins and clarification of their molecular mechanism for the metastasis and drug-resistance of bone and soft tissue sarcoma”.
  • Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan, 2010-11, to Miyako Shimazaki entitled “Investigation of gene pathway playing aggressiveness of micropapillary adenocarcinoma of the lung”.
  • Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan, 2009-10, to Yochimichi Ueda, entitled “Involvement of HMGA-2 and activated genes in its downstream in the progression of non-small cell lung cancer ”.
  • Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan, 2007-9, to Yoshimichi Ueda, entitled “Establishment and application of a novel panel for the gene-analysis involved in tumor cell-host cell communication enhancing the progression of lung cancer”.